People with Parkinson's disease (PD) show impaired decision-making when sensory and
memory information must be combined. This recently identified impairment results from an …

The search for PD-MCI biomarkers has employed an array of neuroimaging techniques, but
still yields divergent findings. This may be due in part to MCI's broad definition …

Objective Whether the dorsal striatum (DS) mediates cognitive control or cognitive effort per
se in decision-making is unclear given that these effects are highly correlated. As the …

Prefrontal cortex plays a vital role in the theory of mind (ToM) and decision making, as
shown in functional brain imaging and lesion studies. Considering the primary …

Rationale Dopaminergic therapy improves some cognitive functions and worsens others in
patients with Parkinson's disease (PD). These paradoxical effects are explained by the …

When facing decisions to approach rewards or to avoid punishments, we often figuratively
go with our gut, and the impact of metabolic states such as hunger on motivation are well …

Dopaminergic therapy has paradoxical effects on cognition in Parkinson's disease (PD)
patients, with some functions worsened and others improved. The dopamine overdose …

The dopamine overdose hypothesis has provided an important theoretical framework for
understanding cognition in Parkinson's disease. It posits that effects of dopaminergic therapy …

Dopamine signaling is thought to mediate reward-based learning. We tested for a role of
dopamine in motor adaptation by administering the dopamine precursor levodopa to healthy …

Dopaminergic therapy has been shown to worsen some cognitive functions, particularly
learning, in Parkinson's disease (PD). This has been attributed to dopamine overdose of …