DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …

DNA repair is an important pathway for the protection of DNA molecules from destruction.
DNA damage can be produced by oxidative reactive nitrogen or oxygen species, irritation …

Melatonin is a ubiquitous molecule found in a wide range of fluids, one of them being ram
seminal plasma, in which it can reach higher concentrations than those found in blood …

Poor development of oocytes from prepubertal animals is a major factor that hinders the
application of the technology, juvenile in vitro embryo transfer (JIVET). The aim of this study …

Melatonin may have beneficial effects when used in oocyte maturation and embryo
development culture. The effect of melatonin during IVM on meiosis resumption and …

Physical damage and oxidative stress may occur in prepubertal cumulus cells, due to
insufficient glutathione synthesis. To determine potential epigenetic mechanisms related to …

Melatonin is a natural hormone synthesised in the pineal gland, the activity of which is
regulated by day–night perception and dictates seasonal rhythms in reproduction in ovine …

Cloned and transgenic pigs are relevant human disease models and serve as potential
donors for regenerative medicine and xenotransplantation. These technologies demand …

Background Melatonin inclusion into in vitro oocyte maturation (IVM) protocols has been
suggested because it possesses a powerful free radical scavenger capability that improves …

Granulosa cells (GCs) play an important role in ovarian follicle growth, development, and
follicular atresia. In the present study, we investigated the effects of Melatonin on bovine …