The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

N Perakakis, K Stefanakis, CS Mantzoros - Metabolism, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose
spectrum covers clinical, histological and pathophysiological developments ranging from …

[HTML][HTML] Diagnosis and management of secondary causes of steatohepatitis

R Liebe, I Esposito, HH Bock, S Vom Dahl, J Stindt… - Journal of …, 2021 - Elsevier
The term non-alcoholic liver disease (NAFLD) was originally coined to describe hepatic fat
deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and …

Association of prenatal exposure to endocrine-disrupting chemicals with liver injury in children

V Midya, E Colicino, DV Conti, K Berhane… - JAMA Network …, 2022 - jamanetwork.com
Importance Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the
risk for liver injury in children; however, human evidence is scarce, and previous studies …

Placebo effect on progression and regression in NASH: evidence from a meta‐analysis

CH Ng, J Xiao, WH Lim, YH Chin, JN Yong, DJH Tan… - Hepatology, 2022 - journals.lww.com
Methods A search was conducted to include NASH RCTs with placebo treatment arms.
Primary outcomes were (1) the resolution of NASH without worsening of fibrosis,(2) two …

Genomics in personalized nutrition: can you “eat for your genes”?

VA Mullins, W Bresette, L Johnstone, B Hallmark… - Nutrients, 2020 - mdpi.com
Genome-wide single nucleotide polymorphism (SNP) data are now quickly and
inexpensively acquired, raising the prospect of creating personalized dietary …

Mini-Review for Journal of HepatologyTherapeutic opportunities for the treatment of NASH with genetically validated targets

D Lindén, S Romeo - Journal of Hepatology, 2023 - Elsevier
The identification of genetic variants associated with fatty liver disease (FLD) from genome
wide association studies (GWASs) started in 2008 when single nucleotide polymorphisms in …

[HTML][HTML] Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease

JP Arab, M Dirchwolf, MR Álvares-da-Silva… - Annals of …, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide.
NAFLD is the most frequently diagnosed chronic liver disease, affecting 20–30% of the …

New-onset age of nonalcoholic fatty liver disease and cancer risk

C Liu, T Liu, Q Zhang, P Jia, M Song… - JAMA Network …, 2023 - jamanetwork.com
Importance The onset age of nonalcoholic fatty liver disease (NAFLD) is decreasing, and
whether earlier ages of NAFLD onset are associated with increased cancer risk is currently …

Nonalcoholic fatty liver disease (NAFLD): pathogenesis and noninvasive diagnosis

V Dorairaj, SA Sulaiman, N Abu, NA Abdul Murad - Biomedicines, 2021 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) or metabolic associated
fatty liver disease (MAFLD), as it is now known, has gradually increased. NAFLD is a …

[HTML][HTML] Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease

P Konyn, A Ahmed, D Kim - Clinical and Molecular Hepatology, 2023 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in the United States and worldwide. Though nonalcoholic fatty liver per se may not be …