Stem cell therapies for wound healing

N Kosaric, H Kiwanuka, GC Gurtner - Expert opinion on biological …, 2019 - Taylor & Francis
Introduction: Aberrant wound healing is a significant healthcare problem, posing a
substantial burden on patients, their families, and the healthcare system. Existing treatment …

Mesenchymal stromal cells as critical contributors to tissue regeneration

GD Sagaradze, NA Basalova, AY Efimenko… - Frontiers in cell and …, 2020 - frontiersin.org
Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell
niche, function to maintain tissue homeostasis and regeneration after damage. This …

[HTML][HTML] Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

Y Gao, Y Chi, Y Chen, W Wang, H Li, W Zheng… - Nature …, 2023 - nature.com
Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been
extensively investigated for their therapeutic potential in treating inflammatory disorders …

Adipogenesis, osteogenesis, and chondrogenesis of human mesenchymal stem/stromal cells: a comparative transcriptome approach

AW Robert, BH Marcon, B Dallagiovanna… - Frontiers in cell and …, 2020 - frontiersin.org
Adipogenesis, osteogenesis and chondrogenesis of human mesenchymal stem/stromal
cells (MSC) are complex and highly regulated processes. Over the years, several studies …

Multi-parameter analysis of biobanked human bone marrow stromal cells shows little influence for donor age and mild comorbidities on phenotypic and functional …

A Andrzejewska, R Catar, J Schoon, TH Qazi… - Frontiers in …, 2019 - frontiersin.org
Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are
among the most frequently tested cellular therapeutics for treating degenerative and immune …

Single-cell RNA-seq highlights heterogeneity in human primary Wharton's jelly mesenchymal stem/stromal cells cultured in vitro

C Sun, L Wang, H Wang, T Huang, W Yao, J Li… - Stem Cell Research & …, 2020 - Springer
Background Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising
application potential in regenerative medicine and immunomodulation. However, MSCs …

Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke

L Zhou, H Zhu, X Bai, J Huang, Y Chen, J Wen… - Stem cell research & …, 2022 - Springer
Ischemic stroke is one of the major causes of death and disability in the world. Currently,
most patients cannot choose intravenous thrombolysis or intravascular mechanical …

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Y Zhou, X Xin, L Wang, B Wang, L Chen… - NPJ Regenerative …, 2021 - nature.com
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines
dramatically with aging. By using a calvarial defect model, we showed that a senolytic …

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

B Wang, Z Liu, VP Chen, L Wang, CL Inman… - Aging cell, 2020 - Wiley Online Library
Adipose‐derived mesenchymal stem cell (ADSC)‐based regenerative therapies have
shown potential for use in many chronic diseases. Aging diminishes stem cell regenerative …

Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

C Medrano-Trochez, P Chatterjee, P Pradhan… - Stem cell research & …, 2021 - Springer
Abstract Background Human Mesenchymal stromal cells (hMSCs) from various tissue
sources are widely investigated in clinical trials. These MSCs are often administered to …