Clinical research is an alternative terminology used to describe medical research. Clinical
research involves people, and it is generally carried out to evaluate the efficacy of a …

The COVID-19 pandemic has presented unique challenges for the clinical trial community,
both in the rapid establishment of COVID-19 clinical trials and many existing non-COVID-19 …

Introduction: Recruitment is an important aspect of clinical research, as poor recruitment
could undermine the scientific value of a trial or delay the development process of new …

Background—Recent studies have investigated alternatives to warfarin for stroke
prophylaxis in patients with atrial fibrillation (AF), but whether these alternatives are cost …

BACKGROUND Close contact casting (CCC) may offer an alternative to open reduction and
internal fixation (ORIF) surgery for unstable ankle fractures in older adults. OBJECTIVES We …

PURPOSE: To evaluate the clinical results and safety obtained with a new type of multifocal
intraocular lens (IOL) using a trifocal design to achieve pseudoaccommodation. METHODS …

Background Many randomised controlled trials (RCT) fail to meet their recruitment goals.
Study personnel play a key role in recruitment. The aim of this study was to identify …

Introduction A considerable number of clinical studies experience delays, which result in
increased duration and costs. In multicentre studies, patient recruitment is among the …

Background Recruitment to randomised controlled trials (RCTs) is often difficult. Clinician
related factors have been implicated as important reasons for low rates of recruitment …

Abstract Background and Objective Model-based and personalised decision support
systems are emerging to guide mechanical ventilation (MV) treatment for respiratory failure …