Glycans are involved in numerous biological recognition events. Being secondary gene
products, their labeling by genetic methods–comparable to GFP labeling of proteins–is not …

The surface of all living cells is decorated with carbohydrate molecules. Hundreds of
functional proteins bind to these glycosylated ligands; such binding events subsequently …

Mucin-type O-glycosylation is a post-translational modification present at the interface
between cells where it has important roles in cellular communication. However, deciphering …

Metabolic labeling of glycans with clickable unnatural sugars has enabled glycan analysis in
multicellular systems. However, cell-type-specific labeling of glycans in vivo remains …

The dynamic cycling of O-linked GlcNAc (O-GlcNAc) on and off Ser/Thr residues of
intracellular proteins, termed O-GlcNAcylation, is mediated by the conserved enzymes O …

The emergence of a polybasic cleavage motif for the protease furin in SARS-CoV-2 spike
has been established as a major factor for human viral transmission. The region N-terminal …

Metabolic oligosaccharide engineering (MOE) is a classical chemical approach to perturb,
profile and perceive glycans in physiological systems, but probes upon bioorthogonal …

Mucins represent a largely untapped class of polymeric building block for biomaterials,
therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically …

Altered glycoprotein expression is an undisputed corollary of cancer development.
Understanding these alterations is paramount but hampered by limitations underlying …

The enzymatic modification of protein serine or threonine residues by N-acetylglucosamine,
namely O-GlcNAcylation, is a ubiquitous post-translational modification that frequently …