Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with
improved bioavailability. Polydatin possesses potential biological activities predominantly …

Polydatin, one of the natural active small molecules, was commonly applied in protecting
and treating liver disorders in preclinical studies. Oxidative stress plays vital roles in liver …

Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)–treated cancer
patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in …

Cisplatin is widely used in the treatment of solid tumors, but its application is greatly limited
due to its nephrotoxicity; thus, there is still no effective medicine for the treatment of cisplatin …

Acrylamide (ACR) is a hazardous substance associated with the accumulation of excessive
reactive oxygen species and causes oxidative stress. Presence of ACR in foods leads to …

Objective (s): 5-fluorouracil-induced (5-FU), an anticarcinogenic agent, is reported to have
side-effects that include hepatotoxicity and nephrotoxicity. The study objective was to …

We sought to determine the effects of selenium (Se) on acrylamide (ACR)-induced
nephrotoxicity in rats. In our study, 50 adult male Sprague-Dawley rats weighing 200–250 g …

The present study was planned to evaluate the protective role of resveratrol (Res) against
subchronic malathion exposure in rats over four weeks. In total, 48 Wistar rats were used …

The aim of this study is to examine the protective effect of naringenin‐oxime (NOX) on
cisplatin‐induced major organ toxicity and DNA damage in rats. Thirty‐five male Wistar …

Paclitaxel is a primary chemotherapy agent that displays antitumor activity against a variety
of solid tumors. However, the clinical effectiveness of the drug is hampered by its …