[HTML][HTML] Dendritic cells as shepherds of T cell immunity in cancer

MJ Pittet, M Di Pilato, C Garris, TR Mempel - Immunity, 2023 - cell.com
In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

Immunogenic cell death in cancer therapy: Present and emerging inducers

J Zhou, G Wang, Y Chen, H Wang… - Journal of cellular and …, 2019 - Wiley Online Library
In the tumour microenvironment (TME), immunogenic cell death (ICD) plays a major role in
stimulating the dysfunctional antitumour immune system. Chronic exposure of damage …

Nanoparticle‐mediated immunogenic cell death enables and potentiates cancer immunotherapy

X Duan, C Chan, W Lin - Angewandte Chemie International …, 2019 - Wiley Online Library
Cancer immunotherapies that train or stimulate the inherent immunological systems to
recognize, attack, and eradicate tumor cells with minimal damage to healthy cells have …

Cross-talk between antigen presenting cells and T cells impacts intestinal homeostasis, bacterial infections, and tumorigenesis

SJ Gaudino, P Kumar - Frontiers in immunology, 2019 - frontiersin.org
Innate immunity is maintained in part by antigen presenting cells (APCs) including dendritic
cells, macrophages, and B cells. APCs interact with T cells to link innate and adaptive …

Recent advances in nanomaterial-based synergistic combination cancer immunotherapy

W Sang, Z Zhang, Y Dai, X Chen - Chemical Society Reviews, 2019 - pubs.rsc.org
In recent years, conventional treatments including surgery, chemotherapy and radiotherapy
have been the main approaches in tumour therapy. Cancer immunotherapy is a new …

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

H Deng, W Yang, Z Zhou, R Tian, L Lin, Y Ma… - Nature …, 2020 - nature.com
Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened
by elevated reactive oxygen species (ROS) in the tumour microenvironment. It is therefore of …

How do cytotoxic lymphocytes kill cancer cells?

L Martínez-Lostao, A Anel, J Pardo - Clinical cancer research, 2015 - AACR
In the past few years, cancer immunotherapy has emerged as a safe and effective
alternative for treatment of cancers that do not respond to classical treatments, including …

Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses

AD Garg, P Agostinis - Immunological reviews, 2017 - Wiley Online Library
The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …

Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress

Z Zhuang, J Dai, M Yu, J Li, P Shen, R Hu, X Lou… - Chemical …, 2020 - pubs.rsc.org
Photodynamic therapy (PDT) is considered a pioneering and effective modality for cancer
treatment, but it is still facing challenges of hypoxic tumors. Recently, Type I PDT, as an …

Nanomaterial-based tumor photothermal immunotherapy

P Xu, F Liang - International journal of nanomedicine, 2020 - Taylor & Francis
In recent years, photothermal therapy (PTT) particularly nanomaterial-based PTT is a
promising therapeutic modality and technique for cancer tumor ablation. In addition to killing …