Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …

Malaria is a great concern for global health and accounts for a large amount of morbidity and
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …

In this work, the degradation of chloroquine (CLQ), an antiviral and antimalarial drug, using
electro-Fenton oxidation was investigated. Due to the importance of hydrogen peroxide (H 2 …

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …

Abstract Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome
caused by Coronavirus 2 (SARS-CoV-2). In the light of its rapid global spreading, on 11 …

Drug‐resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs
and have contributed significantly to the failure to control and eradicate malaria throughout …

Until the end of the 19th century all drugs were natural products or minerals. During the 19th
century chemists succeeded in isolating pure natural products such as quinine, morphine …

Background Chloroquine, a previous highly efficacious, easy to use and affordable anti-
malarial agent was withdrawn from malaria endemic regions due to high levels of …

Background Artemisinin-based combination therapy (ACT) was deployed in 2005 as an
alternative to chloroquine and is considered the most efficacious treatment currently …

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the
major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we …