TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

ABSTRACT Transmembrane member 16A (TMEM16A) is the Ca2+‐activated chloride
channel in airways and intestine. It has been associated with goblet cell metaplasia, as …

Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in
secretory epithelial cells of airways and intestine. Previous studies provided evidence for a …

ABSTRACT The Ca2+‐activated Cl‒channel TMEM16A [anoctamin (ANO) 1] is homologous
to yeast Ist2 and has been shown to tether the cortical endoplasmic reticulum (ER) to the …

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …

Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …

The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …

TMEM16A is a Ca2+ activated Cl− channel with important functions in airways, intestine,
and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic …