Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic
homeostasis. They also play crucial roles during liver injury by communicating with liver cell …

The liver is an immune organ that plays a vital role in the detection, capture, and clearance
of pathogens and foreign antigens that invade the human body. During acute and chronic …

The energy-burning capability of beige adipose tissue is a potential therapeutic tool for
reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we …

There is a paucity of human models to study immune-mediated host damage. Here, we
utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID …

While spatial transcriptomics has undeniably revolutionized our ability to study cellular
organization, it has driven the development of a great number of innovative transcriptomics …

Spatial transcriptomics, leveraging sequencing-and imaging-based techniques, has
emerged as a groundbreaking technology for mapping gene expression within the complex …

Background: ACT001 is a potent anti-inflammatory small-molecule drug. However, the
single cell and spatial molecular basis of pyroptosis and whether ACT001 exerts a …