Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance

Y Yao, Y Zhou, L Liu, Y Xu, Q Chen, Y Wang… - Frontiers in molecular …, 2020 - frontiersin.org
Nanotechnology has been extensively studied and exploited for cancer treatment as
nanoparticles can play a significant role as a drug delivery system. Compared to …

Targeting hypoxic tumor microenvironment in pancreatic cancer

J Tao, G Yang, W Zhou, J Qiu, G Chen, W Luo… - Journal of hematology & …, 2021 - Springer
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

DNA hydrogel-based gene editing and drug delivery systems

F Mo, K Jiang, D Zhao, Y Wang, J Song… - Advanced Drug Delivery …, 2021 - Elsevier
Deoxyribonucleic acid (DNA) is a promising synthesizer for precisely constructing almost
arbitrary geometry in two and three dimensions. Among various DNA-based soft materials …

Ferrous-supply-regeneration nanoengineering for cancer-cell-specific ferroptosis in combination with imaging-guided photodynamic therapy

T Liu, W Liu, M Zhang, W Yu, F Gao, C Li, SB Wang… - Acs Nano, 2018 - ACS Publications
Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the
inevitable biocarriers of traditional apoptotic therapeutic means. Inspired by industrial electro …

Injectable immunotherapeutic hydrogel containing RNA-loaded lipid nanoparticles reshapes tumor microenvironment for pancreatic cancer therapy

C Gao, K Cheng, Y Li, R Gong, X Zhao, G Nie… - Nano …, 2022 - ACS Publications
Pancreatic cancer immunotherapy is becoming a promising strategy for improving the
survival rate of postsurgical patients. However, the low response rate to immunotherapy …

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Y Dai, C Xu, X Sun, X Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared
with normal tissue, the tumour microenvironment has some unique properties, such as …

Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer

Z Liu, N Parveen, U Rehman, A Aziz, A Sheikh… - Molecular Cancer, 2023 - Springer
Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor
prognosis can be attributed to both troublesome detections at the initial stage, which makes …

Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles

M Alavi, M Hamidi - Drug metabolism and personalized therapy, 2019 - degruyter.com
Considerable development in the application of injectable drug delivery systems for cancer
therapy has occurred in the last few decades. These improvements include liposomes, lipid …

Polymeric DNA hydrogel: Design, synthesis and applications

F Li, J Tang, J Geng, D Luo, D Yang - Progress in Polymer Science, 2019 - Elsevier
Deoxyribonucleic acid (DNA) stores genetic information as a biomolecule, and also is
regarded as a block copolymer and polyanion. Under favorable environments, DNA …

Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

F Li, W Yu, J Zhang, Y Dong, X Ding, X Ruan… - Nature …, 2021 - nature.com
DNA nanostructures have been demonstrated as promising carriers for gene delivery. In the
carrier design, spatiotemporally programmable assembly of DNA under nanoconfinement is …