Regulation by small RNAs in bacteria: expanding frontiers

G Storz, J Vogel, KM Wassarman - Molecular cell, 2011 - cell.com
Research on the discovery and characterization of small, regulatory RNAs in bacteria has
exploded in recent years. These sRNAs act by base pairing with target mRNAs with which …

Hfq chaperone brings speed dating to bacterial sRNA

A Santiago‐Frangos… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea.
Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their …

Identification of bacteriophage-encoded anti-sRNAs in pathogenic Escherichia coli

JJ Tree, S Granneman, SP McAteer, D Tollervey… - Molecular cell, 2014 - cell.com
In bacteria, Hfq is a core RNA chaperone that catalyzes the interaction of mRNAs with
regulatory small RNAs (sRNAs). To determine in vivo RNA sequence requirements for Hfq …

Molecular mechanism of mRNA repression in trans by a ProQ‐dependent small RNA

A Smirnov, C Wang, LL Drewry, J Vogel - The EMBO journal, 2017 - embopress.org
Research into post‐transcriptional control of mRNAs by small noncoding RNAs (sRNAs) in
the model bacteria Escherichia coli and Salmonella enterica has mainly focused on sRNAs …

Competing endogenous RNAs: a target-centric view of small RNA regulation in bacteria

L Bossi, N Figueroa-Bossi - Nature Reviews Microbiology, 2016 - nature.com
Many bacterial regulatory small RNAs (sRNAs) have several mRNA targets, which places
them at the centre of regulatory networks that help bacteria to adapt to environmental …

RNA-binding proteins involved in post-transcriptional regulation in bacteria

E Van Assche, S Van Puyvelde… - Frontiers in …, 2015 - frontiersin.org
Post-transcriptional regulation is a very important mechanism to control gene expression in
changing environments. In the past decade, a lot of interest has been directed toward the …

On the importance of cotranscriptional RNA structure formation

D Lai, JR Proctor, IM Meyer - Rna, 2013 - rnajournal.cshlp.org
The expression of genes, both coding and noncoding, can be significantly influenced by
RNA structural features of their corresponding transcripts. There is by now mounting …

Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression

E Sonnleitner, U Bläsi - PLoS Genetics, 2014 - journals.plos.org
Carbon Catabolite repression (CCR) allows a fast adaptation of Bacteria to changing
nutrient supplies. The Pseudomonas aeruginosa (PAO1) catabolite repression control …

Small RNAs and Hfq capture unfolded RNA target sites during transcription

ML Rodgers, B O'Brien, SA Woodson - Molecular cell, 2023 - cell.com
Small ribonucleoproteins (sRNPs) target nascent precursor RNAs to guide folding,
modification, and splicing during transcription. Yet, rapid co-transcriptional folding of the …

The bacterial protein Hfq: much more than a mere RNA-binding factor

P Sobrero, C Valverde - Critical reviews in microbiology, 2012 - Taylor & Francis
Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq
that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally …