Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …

Rab7 is a small GTPase that belongs to the Rab family and controls transport to late
endocytic compartments such as late endosomes and lysosomes. The mechanism of action …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Membrane fusion is generally controlled by Rabs, soluble N-ethylmaleimide–sensitive factor
attachment protein receptors (SNAREs), and tethering complexes. Syntaxin 17 (STX17) was …

Protein and lipid transport along the endolysosomal system of eukaryotic cells depends on
multiple fusion and fission events. Over the past few years, the molecular constituents of …

The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …

Cellular life depends on continuous transport of lipids and small molecules between
mitochondria and the endomembrane system. Recently, endoplasmic reticulum …

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic
components, including cytosol and organelles, to the lysosome in double-membrane …