Low muscle strength is an important heritable indicator of poor health linked to morbidity and
mortality in older people. In a genome-wide association study meta-analysis of 256,523 …

The Golgi apparatus (GA) is involved in a whole spectrum of activities, from lipid
biosynthesis and membrane secretion to the posttranslational processing and trafficking of …

The Golgi apparatus plays a central role in cell homeostasis, not only in processing and
maturing newly synthesized proteins and lipids but also in orchestrating their sorting …

Evolutionary constraints may significantly bias phenotypic change, while “breaking” from
such constraints can lead to expanded ecological opportunity. Ray-finned fishes have …

Background Establishing the genetic basis of phenotypes such as skeletal dysplasia in
model organisms can provide insights into biologic processes and their role in human …

The conserved oligomeric Golgi (COG) complex is involved in intracellular vesicular
transport, and is composed of eight subunits distributed in two lobes, lobe A (COG1-4) and …

Abstract Desbuquois dysplasia type 1 (DBQD1) is a chondrodysplasia caused by mutations
in CANT1 gene encoding an ER/Golgi calcium activated nucleotidase 1 that hydrolyses …

Abstract Dyggve-Melchior-Clausen dysplasia (DMC) is a rare inherited dwarfism with severe
mental retardation due to mutations in the DYM gene which encodes Dymeclin, a 669-amino …

Dymeclin is a Golgi-associated protein whose deficiency causes Dyggve–Melchior–Clausen
syndrome (DMC, MIM# 223800), a rare recessively inherited spondyloepimetaphyseal …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor with
rapid progression and poor prognosis. In the present study, 11 high‑quality microarray …