Nrf2/HO-1 as a therapeutic target in renal fibrosis
EHM Hassanein, IM Ibrahim, EK Abd-Alhameed… - Life Sciences, 2023 - Elsevier
Chronic kidney disease (CKD) is one of the most prevalent chronic diseases and affects
between 10 and 14% of the world's population. The World Health Organization estimates …
between 10 and 14% of the world's population. The World Health Organization estimates …
Biglycan: a regulator of hepatorenal inflammation and autophagy
Soluble biglycan, a small leucine-rich proteoglycan, plays a significant role in several
pathologies as it has emerged as an extracellular matrix-derived danger-associated …
pathologies as it has emerged as an extracellular matrix-derived danger-associated …
The mechanisms of arsenic-induced ovotoxicity, ultrastructural alterations, and autophagic related paths: An enduring developmental study in folliculogenesis of mice
Arsenic (As) exerts a wide range of adverse effects on biological systems, including the
reproductive organs in males and females. However, the mechanisms of As-induced …
reproductive organs in males and females. However, the mechanisms of As-induced …
The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity
A Ahmadi, H Niknahad, H Li, A Mobasheri… - Toxicology Letters, 2021 - Elsevier
The cholestatic liver injury could occur in response to a variety of diseases or xenobiotics.
Although cholestasis primarily affects liver function, it has been well-known that other organs …
Although cholestasis primarily affects liver function, it has been well-known that other organs …
Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of …
Lead (Pb) is a highly toxic heavy metal widely dispersed in the environment because of
human industrial activities. Many studies revealed that Pb could adversely affect several …
human industrial activities. Many studies revealed that Pb could adversely affect several …
The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury
K Mousavi, H Niknahad, H Li, Z Jia… - Toxicology …, 2021 - academic.oup.com
Cholestasis is a severe clinical complication that severely damages the liver. Kidneys are
also the most affected extrahepatic organs in cholestasis. The pivotal role of oxidative stress …
also the most affected extrahepatic organs in cholestasis. The pivotal role of oxidative stress …
Paternal exposure to arsenic resulted in oxidative stress, autophagy, and mitochondrial impairments in the HPG axis of pubertal male offspring
Despite the knowledge of AS-induced reprotoxicity, the literature concerning arsenic trioxide
(As 2 O 3)-induced oxidative stress and consequent intracellular events, like autophagy …
(As 2 O 3)-induced oxidative stress and consequent intracellular events, like autophagy …
Cholestasis-associated reproductive toxicity in male and female rats: The fundamental role of mitochondrial impairment and oxidative stress
Cholestasis is a significant decrease in bile flow. The liver is the primary organ affected by
cholestasis. Chronic cholestasis could entail to tissue fibrotic changes and liver cirrhosis …
cholestasis. Chronic cholestasis could entail to tissue fibrotic changes and liver cirrhosis …
Poly (ADP-Ribose) polymerase-1 (PARP-1) overactivity plays a pathogenic role in bile acids-induced nephrotoxicity in cholestatic rats
A Siavashpour, B Khalvati, N Azarpira, H Mohammadi… - Toxicology letters, 2020 - Elsevier
Cholestatic liver disease is a clinical complication with a wide range of etiologies. The liver
is the primary organ influenced by cholestasis. Other organs, rather than the liver (eg …
is the primary organ influenced by cholestasis. Other organs, rather than the liver (eg …
Cholestasis-associated pulmonary inflammation, oxidative stress, and tissue fibrosis: The protective role of the biogenic amine agmatine
Introduction: Cholestasis is the stoppage of bile flow, leading to the accumulation of
potentially cytotoxic bile components in the liver. These cytotoxic molecules affect many …
potentially cytotoxic bile components in the liver. These cytotoxic molecules affect many …