Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

A Yilmaz, H Cui, MA Caligiuri, J Yu - Journal of hematology & oncology, 2020 - Springer
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …

CAR-NK cells: from natural basis to design for kill

MB Khawar, H Sun - Frontiers in immunology, 2021 - frontiersin.org
Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

Overcoming tumor resistance mechanisms in CAR-NK cell therapy

A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …

Immunotherapy for hepatocellular carcinoma: recent advances and future targets

SJ Yu - Pharmacology & Therapeutics, 2023 - Elsevier
Immunotherapy is a promising approach to treating various types of cancers, including
hepatocellular carcinoma (HCC). While single immunotherapy drugs show limited …

[HTML][HTML] The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy

KP Fabian, JW Hodge - Molecular Therapy-Oncolytics, 2021 - cell.com
Natural killer (NK) cells are innate lymphocytes that recognize and clear infected and
transformed cells. The importance of NK cells in tumor surveillance underlies the …

A functional chemiluminescent probe for in vivo imaging of natural killer cell activity against tumours

JI Scott, S Gutkin, O Green… - Angewandte Chemie …, 2021 - Wiley Online Library
Natural killer (NK) cells are immune cells that can kill certain types of cancer cells. Adoptive
transfer of NK cells represents a promising immunotherapy for malignant tumours; however …

Chimeric antigen receptor-and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

C Zhang, Y Hu, W Xiao, Z Tian - Cellular & Molecular Immunology, 2021 - nature.com
Chimeric antigen receptor (CAR)-engineered T-cell (CAR-T) therapy has demonstrated
impressive therapeutic efficacy against hematological malignancies, but multiple challenges …

[HTML][HTML] Emerging NK cell therapies for cancer and the promise of next generation engineering of iPSC-derived NK cells

S Maddineni, JL Silberstein… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Adoptive cell therapy is a rapidly advancing approach to cancer immunotherapy that seeks
to facilitate antitumor responses by introducing potent effector cells into the tumor …

Myeloid-derived suppressor cells in solid tumors

T Ma, BW Renz, M Ilmer, D Koch, Y Yang, J Werner… - Cells, 2022 - mdpi.com
Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population
of the immune system. They play a pivotal role in the establishment of the tumor …