The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Mapping epigenetic modifications by sequencing technologies
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
Small RNA modifications: regulatory molecules and potential applications
Q Xiong, Y Zhang - Journal of Hematology & Oncology, 2023 - Springer
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …
Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination
Abstract N6-methyladenosine (m6A) and pseudouridine (Ψ) are the two most abundant
modifications in mammalian messenger RNA, but the coordination of their biological …
modifications in mammalian messenger RNA, but the coordination of their biological …
Single-nucleus multiomic mapping of m6A methylomes and transcriptomes in native populations of cells with sn-m6A-CT
Summary N 6-methyladenosine (m 6 A) RNA modification plays important roles in the
governance of gene expression and is temporally regulated in different cell states. In …
governance of gene expression and is temporally regulated in different cell states. In …
Quantifying m6A and Ψ Modifications in the Transcriptome via Chemical-Assisted Approaches
Conspectus Since the discovery of the first chemically modified RNA nucleotide in 1951,
more than 170 types of chemical modifications have been characterized in RNA so far …
more than 170 types of chemical modifications have been characterized in RNA so far …
Base-resolution sequencing methods for whole-transcriptome quantification of mRNA modifications
Conspectus RNA molecules are not merely a combination of four bases of A, C, G, and U.
Chemical modifications occur in almost all RNA species and play diverse roles in gene …
Chemical modifications occur in almost all RNA species and play diverse roles in gene …
An adenine base editor variant expands context compatibility
Adenine base editors (ABEs) are precise gene-editing agents that convert A: T pairs into G:
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …
The rise of epitranscriptomics: recent developments and future directions
The epitranscriptomics field has undergone tremendous growth since the discovery that the
RNA N 6-methyladenosine (m 6 A) modification is reversible and is distributed throughout …
RNA N 6-methyladenosine (m 6 A) modification is reversible and is distributed throughout …
Enhancing clinical potential of liquid biopsy through a multi-omic approach: A systematic review
G Di Sario, V Rossella, ES Famulari, A Maurizio… - Frontiers in …, 2023 - frontiersin.org
In the last years, liquid biopsy gained increasing clinical relevance for detecting and
monitoring several cancer types, being minimally invasive, highly informative and replicable …
monitoring several cancer types, being minimally invasive, highly informative and replicable …