Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

The immune landscape of a tumor is highly connected to patient prognosis and response to
treatment, but little is known about how natural killer (NK) cells predict overall survival (OS) …

Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

Allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-haploidentical
relative (haplo-HSCT) is a suitable option for children with acute leukemia (AL) either …

Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …

Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …

NK cells are a major component of the antitumor immune response and are involved in
controlling tumor progression and metastases in animal models. Here, we show that …

Posttransplant relapse is still the major cause of treatment failure in high-risk acute
leukemia. Attempts to manipulate alloreactive T cells to spare normal cells while killing …

Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large
granular lymphocytes that belong to the innate immune system because unlike T or B …