Therapies for allergic inflammation: refining strategies to induce tolerance

CA Akdis - Nature medicine, 2012 - nature.com
Current therapies for asthma and allergy are relatively safe and effective at controlling
symptoms but do not change the chronic course of disease. There is no established method …

Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation

AL Silva, C Peres, J Conniot, AI Matos, L Moura… - Seminars in …, 2017 - Elsevier
Nanotechnology-based strategies can dramatically impact the treatment, prevention and
diagnosis of a wide range of diseases. Despite the unprecedented success achieved with …

Advances in allergen immunotherapy: aiming for complete tolerance to allergens

CA Akdis, M Akdis - Science translational medicine, 2015 - science.org
Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a
tolerance-inducing therapy for allergic diseases and represents a potentially curative …

The major cat allergen, Fel d 1, in diagnosis and therapy

H Grönlund, T Saarne, G Gafvelin… - International archives of …, 2010 - karger.com
Sensitization to cat is a common cause of allergic disease all over the world. Symptoms
range from mild rhinoconjunctivitis to potentially life-threatening asthmatic exacerbations. In …

Mechanisms of allergen-specific immunotherapy and novel ways for vaccine development

M Jutel, W Van de Veen, I Agache, KA Azkur… - Allergology …, 2013 - Elsevier
Allergen-specific immunotherapy (SIT) is the only available curative treatment of allergic
diseases. Recent evidence provided a plausible explanation to its multiple mechanisms …

Recent advances in the use of nanoparticles for allergen‐specific immunotherapy

H Pohlit, I Bellinghausen, H Frey, J Saloga - Allergy, 2017 - Wiley Online Library
The number of patients suffering from allergic asthma and rhinoconjunctivitis has increased
dramatically within the last decades. Allergen‐specific immunotherapy (AIT) is the only …

Current possibilities and future perspectives for improving efficacy of allergen-specific sublingual immunotherapy

M Sadeghi, SK Shahbaz, S Dehnavi, K Koushki… - International …, 2021 - Elsevier
Allergen-specific sublingual immunotherapy (SLIT), a safe and efficient route for treating
type I hypersensitivity disorders, requires high doses of allergens. SLIT is generally …

Allergen‐specific immunotherapy: is it vaccination against toxins after all?

MF Bachmann, TM Kündig - Allergy, 2017 - Wiley Online Library
IgE‐mediated allergies, in particular allergic rhinoconjunctivitis and asthma, have reached
epidemic proportions, affecting about one‐third of the population in developed countries …

Improved immune responses in mice using the novel chitosan adjuvant ViscoGel, with a Haemophilus influenzae type b glycoconjugate vaccine

T Neimert-Andersson, AC Hällgren, M Andersson… - Vaccine, 2011 - Elsevier
An immune response to an antigen is more efficiently induced in combination with an
adjuvant. Chitosan has due to documented immunostimulatory characteristics been …

Mammalian-derived respiratory allergens–implications for diagnosis and therapy of individuals allergic to furry animals

OB Nilsson, M van Hage, H Grönlund - Methods, 2014 - Elsevier
Furry animals cause respiratory allergies in a significant proportion of the population. A
majority of all mammalian allergens are spread as airborne particles, and several have been …