[HTML][HTML] Structural studies of the TGF-βs and their receptors–insights into evolution of the TGF-β superfamily
AP Hinck - FEBS letters, 2012 - Elsevier
TGF-βs are small secreted signaling proteins that function as vital regulators of cellular
growth and differentiation. They signal through a single pair of receptors, known as TβR-I …
growth and differentiation. They signal through a single pair of receptors, known as TβR-I …
Specification of BMP signaling
J Nickel, TD Mueller - Cells, 2019 - mdpi.com
Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors
(GDFs) form the largest subgroup of the Transforming Growth Factor (TGF) β family and …
(GDFs) form the largest subgroup of the Transforming Growth Factor (TGF) β family and …
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
CJC Johnston, DJ Smyth, RB Kodali, MPJ White… - Nature …, 2017 - nature.com
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms,
including activation of host immunosuppressive regulatory T (Treg) cells. The mouse …
including activation of host immunosuppressive regulatory T (Treg) cells. The mouse …
Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED
Traditionally, crystallographic analysis of macromolecules has depended on large, well-
ordered crystals, which often require significant effort to obtain. Even sizable crystals …
ordered crystals, which often require significant effort to obtain. Even sizable crystals …
Cooperative assembly of TGF-β superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
Dimeric ligands of the transforming growth factor-β (TGF-β) superfamily signal across cell
membranes in a distinctive manner by assembling heterotetrameric complexes of …
membranes in a distinctive manner by assembling heterotetrameric complexes of …
Ternary complex of transforming growth factor-β1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Transforming growth factor (TGF)-β1,-β2, and-β3 are 25-kDa homodimeric polypeptides that
play crucial nonoverlapping roles in embryogenesis, tissue development, carcinogenesis …
play crucial nonoverlapping roles in embryogenesis, tissue development, carcinogenesis …
The structural basis of TGF-β, bone morphogenetic protein, and activin ligand binding
SJ Lin, TF Lerch, RW Cook, TS Jardetzky… - …, 2006 - rep.bioscientifica.com
The transforming growth factor-β (TGF-β) superfamily is a large group of structurally related
growth factors that play prominent roles in a variety of cellular processes. The importance …
growth factors that play prominent roles in a variety of cellular processes. The importance …
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor
D Weber, A Kotzsch, J Nickel, S Harth, A Seher… - BMC structural …, 2007 - Springer
Abstract Background Bone morphogenetic proteins (BMPs) are key regulators in the
embryonic development and postnatal tissue homeostasis in all animals. Loss of function or …
embryonic development and postnatal tissue homeostasis in all animals. Loss of function or …
TGF‐β signalling is mediated by two autonomously functioning TβRI: TβRII pairs
Transforming growth factor (TGF)‐βs are dimeric polypeptides that have vital roles in
regulating cell growth and differentiation. They signal by assembling a receptor …
regulating cell growth and differentiation. They signal by assembling a receptor …
Structural perspective of BMP ligands and signaling
GR Gipson, EJ Goebel, KN Hart, EC Kappes… - Bone, 2020 - Elsevier
Abstract The Bone Morphogenetic Proteins (BMPs) are the largest class signaling molecules
within the greater Transforming Growth Factor Beta (TGFβ) family, and are responsible for a …
within the greater Transforming Growth Factor Beta (TGFβ) family, and are responsible for a …