An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19

S Yasamineh, HG Kalajahi, P Yasamineh… - Journal of …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to COVID-19 and has
become a pandemic worldwide with mortality of millions. Nanotechnology can be used to …

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

D Ao, X He, J Liu, L Xu - Signal Transduction and Targeted Therapy, 2023 - nature.com
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in significant casualties and put immense strain on public health systems worldwide, leading …

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

S Ambike, CC Cheng, M Feuerherd… - Nucleic acids …, 2022 - academic.oup.com
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …

Therapeutic siRNA: state-of-the-art and future perspectives

M Friedrich, A Aigner - BioDrugs, 2022 - Springer
The highly specific induction of RNA interference-mediated gene knockdown, based on the
direct application of small interfering RNAs (siRNAs), opens novel avenues towards …

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

VN Hariharan, M Shin, CW Chang… - Proceedings of the …, 2023 - National Acad Sciences
The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing
pandemic, underscoring the need for a dynamic platform for the rapid development of pan …

Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches

W Wang, Z Huang, Y Huang, X Zhang, J Huang… - Advanced Drug Delivery …, 2022 - Elsevier
Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant

YC Chang, CF Yang, YF Chen, CC Yang… - EMBO molecular …, 2022 - embopress.org
The emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
variants has altered the trajectory of the COVID‐19 pandemic and raised some uncertainty …

Dendrimers, an emerging opportunity in personalized medicine?

AM Caminade - Journal of personalized medicine, 2022 - mdpi.com
Dendrimers are highly branched macromolecules tailorable at will to fulfil precise
requirements. They have generated a great many expectations and a huge number of …

[HTML][HTML] siRNA therapeutics and its challenges: Recent advances in effective delivery for cancer therapy

A Paul, A Muralidharan, A Biswas, BV Kamath… - OpenNano, 2022 - Elsevier
Small interfering RNA (siRNA) has emerged as a promising strategy for treating several
“undruggable” genetically impaired conditions. The siRNA-based drugs have opened the …

Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes

J Wang, G Chen, N Liu, X Han, F Zhao, L Zhang… - Advances in Colloid and …, 2022 - Elsevier
In the past decades, the striking development of cationic polypeptides and cell-penetrating
peptides (CPPs) tailored for small interfering RNA (siRNA) delivery has been fuelled by the …