Mitochondrial signal transduction

M Picard, OS Shirihai - Cell Metabolism, 2022 - cell.com
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Social determinants of cardiovascular disease

TM Powell-Wiley, Y Baumer, FO Baah… - Circulation …, 2022 - Am Heart Assoc
Social determinants of health (SDoH), which encompass the economic, social,
environmental, and psychosocial factors that influence health, play a significant role in the …

Hallmarks of health

C López-Otín, G Kroemer - Cell, 2021 - cell.com
Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

The multiple roles of life stress in metabolic disorders

M Kivimäki, A Bartolomucci, I Kawachi - Nature Reviews Endocrinology, 2023 - nature.com
The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but
excessive stress can damage body functions. We review current evidence from basic …

The default network of the human brain is associated with perceived social isolation

RN Spreng, E Dimas, L Mwilambwe-Tshilobo… - Nature …, 2020 - nature.com
Humans survive and thrive through social exchange. Yet, social dependency also comes at
a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive …

Resilience during uncertainty? Greater social connectedness during COVID‐19 lockdown is associated with reduced distress and fatigue

JP Nitschke, PAG Forbes, N Ali, J Cutler… - British journal of …, 2021 - Wiley Online Library
Background Social connections are crucial for our health and well‐being. This is especially
true during times of high uncertainty and distress, such as during the COVID‐19 lockdown …

COVID-19: rethinking the lockdown groupthink

AR Joffe - Frontiers in public health, 2021 - frontiersin.org
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused the
Coronavirus Disease 2019 (COVID-19) worldwide pandemic in 2020. In response, most …

[HTML][HTML] The energetic cost of allostasis and allostatic load

N Bobba-Alves, RP Juster, M Picard - Psychoneuroendocrinology, 2022 - Elsevier
Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Sociability as a personality trait in animals: methods, causes and consequences

LA Gartland, JA Firth, KL Laskowski… - Biological …, 2022 - Wiley Online Library
Within animal populations there is variation among individuals in their tendency to be social,
where more sociable individuals associate more with other individuals. Consistent inter …

Social thinning and stress generation after childhood maltreatment: A neurocognitive social transactional model of psychiatric vulnerability

E McCrory, L Foulkes, E Viding - The Lancet Psychiatry, 2022 - thelancet.com
Childhood maltreatment is associated with significant, enduring risk of psychiatric disorder.
In this paper, we review how neurocognitive alterations after maltreatment might indirectly …