Renin–angiotensin–aldosterone system (RAAS) inhibitors are standard care in patients with
hypertension, heart failure or chronic kidney disease (CKD). Although we have studied the …

Neprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various
bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous …

Background: The Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive
lowering of systolic blood pressure (BP) increased the risk of incident chronic kidney …

A well-known link exists between cerebrovascular disease and chronic kidney disease.
Cerebrovascular pathology in patients with kidney disease may be asymptomatic and …

Objectives Chronic kidney disease (CKD) is a serious health issue with rising morbidity and
mortality rates. Despite advances in understanding its pathophysiology, effective therapeutic …

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Background The optimisation of patients in primary care is a prime opportunity to manage
patient care within the community and reduce the burden of referrals on secondary care …

Challenging the Restrictive Approach: Reconsidering Sodium-Glucose Transport Protein 2
Inhibitor Use in CKD - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Chronic kidney disease (CKD) is a major global health issue, projected to become the fifth
leading cause of mortality by 2040. Renal tubular cell senescence is a key driver of kidney …

The proposed chapter will involve role of different mechanisms in renin-angiotensin system
(RAS) leads to regulation of blood pressure and diseases such as hypertension, heart …