▪ Abstract The genomes from three mammals (human, mouse, and rat), two worms, and
several yeasts have been sequenced, and more genomes will be completed in the near …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

Comparative sequence analysis has become an essential component of studies aiming to
elucidate genome function. The increasing availability of genomic sequences from multiple …

The combination of bioinformatic and biological approaches constitutes a powerful method
for identifying gene regulatory elements. High-quality genome sequences are available in …

Transcription factors are key regulators of hematopoietic stem cells (HSCs), yet the
molecular mechanisms that control their expression are largely unknown. Previously, we …

A problem of substantial interest is to systematically map variation in chromatin structure to
gene-expression regulation across conditions, environments, or differentiated cell types. We …

Development can be viewed as a dynamic progression through regulatory states which
characterise the various cell types within a given differentiation cascade. To understand the …

Sequencing and comparative analyses of genomes from multiple vertebrates are providing
insights about the genetic basis for biological diversity. To date, these efforts largely have …

The GATA-1–interacting protein Friend Of GATA-1 (FOG-1) is essential for the proper
transcriptional activation and repression of numerous GATA-1 target genes. Although FOG-1 …

OBJECTIVE: Key regulators of blood stem cell differentiation into the various mature
hematopoietic lineages are commonly encoded by transcription factor genes. Elucidation of …