Fast and deep phosphoproteome analysis with the Orbitrap Astral mass spectrometer
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles
in myriad cell processes. That said, detecting and quantifying protein phosphorylation has …
in myriad cell processes. That said, detecting and quantifying protein phosphorylation has …
[HTML][HTML] CAMK2; four genes, one syndrome? Delineation of genotype–phenotype correlations
JS Cheung, GM van Woerden, DCM Veenma - Current Opinion in …, 2025 - Elsevier
Highlights•CAMK2 related disorders are caused by pathological variants in all four
paralogs.•The vast majority of CAMK2 variants are unique missense variants.•Despite …
paralogs.•The vast majority of CAMK2 variants are unique missense variants.•Despite …
Ligand‐induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity
D Narayanan, ASG Larsen, SJ Gauger… - Protein …, 2024 - Wiley Online Library
Abstract γ‐Hydroxybutyric acid (GHB) analogs are small molecules that bind competitively to
a specific cavity in the oligomeric CaMKIIα hub domain. Binding affects conformation and …
a specific cavity in the oligomeric CaMKIIα hub domain. Binding affects conformation and …
Self-organizing human heart assembloids with autologous and developmentally relevant cardiac neural crest-derived tissues
Neural crest cells (NCCs) are a multipotent embryonic cell population of ectodermal origin
that extensively migrate during early development and contribute to the formation of multiple …
that extensively migrate during early development and contribute to the formation of multiple …
GestaltMatcher Database-A global reference for facial phenotypic variability in rare human diseases
The most important factor that complicates the work of dysmorphologists is the significant
phenotypic variability of the human face. Next-Generation Phenotyping (NGP) tools that …
phenotypic variability of the human face. Next-Generation Phenotyping (NGP) tools that …
Temporal proteomic and PTMomic atlas of cerebral organoid development
SB Elmkvist, H Bogetofte, P Jensen, LA Jakobsen… - bioRxiv, 2024 - biorxiv.org
Cerebral organoids (CBOs) are generated from pluripotent stem cells that undergo
neuroectoderm specification and neuronal differentiation in three dimensions. The …
neuroectoderm specification and neuronal differentiation in three dimensions. The …
Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition
D Narayanan, ASG Larsen, SJ Gauger, R Adafia… - bioRxiv, 2024 - biorxiv.org
γHydroxybutyric acid (GHB) analogs are small molecules that bind competitively to a specific
cavity in the oligomeric CaMKIIα hub domain. Binding affects conformation and stability of …
cavity in the oligomeric CaMKIIα hub domain. Binding affects conformation and stability of …
GestaltMatcher Database-A global reference for facial phenotypic variability in rare human diseases
The most important factor that complicates the work of dysmorphologists is the significant
phenotypic variability of the human face. Next-Generation Phenotyping (NGP) tools that …
phenotypic variability of the human face. Next-Generation Phenotyping (NGP) tools that …