The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated
in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

Glutaminase (GLS) isoenzymes GLS1 and GLS2 are key enzymes for glutamine
metabolism. Interestingly, GLS1 and GLS2 display contrasting functions in tumorigenesis …

The high efficiency of Ag processing and presentation by B cells requires Ag-induced BCR
signaling and actin cytoskeleton reorganization, although the underlying mechanism for …

Rho guanosine triphosphatases (GTPases) are a family of small proteins which function as
molecular switches in a variety of signaling pathways following stimulation of cell surface …

Rho GTPases regulate multiple cellular processes including actin cytoskeletal
rearrangements, transcriptional regulation, and oxidant production. The studies described …

Protein motions are important to activity, but quantitative relationships between internal
dynamics and function are not well understood. The Dbl homology (DH) domain of the proto …

NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O 2−), which has
functions in both cell signaling and immune defense. NOX2 is a multimeric-protein complex …

Although few epidemiological studies have demonstrated that C-reactive protein (CRP) is
related to insulin resistance, no study to date has examined the molecular mechanism. Here …

We have previously shown that redox agents including superoxide anion radical and
nitrogen dioxide can react with GXXXXGK (S/T) C motif-containing GTPases (ie, Rac1 …