[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

MAM Jahromi, PS Zangabad, SMM Basri… - Advanced drug delivery …, 2018 - Elsevier
According to the latest report from the World Health Organization, an estimated 265,000
deaths still occur every year as a direct result of burn injuries. A widespread range of these …

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

M Bosch, M Sánchez-Álvarez, A Fajardo… - Science, 2020 - science.org
INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …

Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Control of phagocytosis by microbial pathogens

E Uribe-Querol, C Rosales - Frontiers in immunology, 2017 - frontiersin.org
Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies

F Alcayaga-Miranda, J Cuenca, M Khoury - Frontiers in immunology, 2017 - frontiersin.org
While mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are
concerns regarding possible side effects related to the unwanted suppression of …

[HTML][HTML] Vitamin D-cathelicidin axis: at the crossroads between protective immunity and pathological inflammation during infection

C Chung, P Silwal, I Kim, RL Modlin, EK Jo - Immune network, 2020 - ncbi.nlm.nih.gov
Vitamin D signaling plays an essential role in innate defense against intracellular
microorganisms via the generation of the antimicrobial protein cathelicidin. In addition to …

Resistance mechanisms to antimicrobial peptides in gram-positive bacteria

L Assoni, B Milani, MR Carvalho… - Frontiers in …, 2020 - frontiersin.org
With the alarming increase of infections caused by pathogenic multidrug-resistant bacteria
over the last decades, antimicrobial peptides (AMPs) have been investigated as a potential …

Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37

M Tatsuta, K Kan-o, Y Ishii, N Yamamoto, T Ogawa… - Respiratory …, 2019 - Springer
Background Airway epithelial barrier function is maintained by the formation of tight
junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway …

Structure–activity relationships of antibacterial peptides

MG Ciulla, F Gelain - Microbial biotechnology, 2023 - Wiley Online Library
Antimicrobial peptides play a crucial role in innate immunity, whose components are mainly
peptide‐based molecules with antibacterial properties. Indeed, the exploration of the …