The hematopoietic stem cell niche: from embryo to adult
Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during
embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and …
embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and …
Human haematopoietic stem cell development: from the embryo to the dish
Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …
haematopoietic system. Understanding how early haematopoietic development occurs is of …
Tracing haematopoietic stem cell formation at single-cell resolution
Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …
Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages
A Ditadi, CM Sturgeon, J Tober, G Awong… - Nature cell …, 2015 - nature.com
The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the …
(hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the …
Lung megakaryocytes display distinct transcriptional and phenotypic properties
Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
Epigenetic regulators as the gatekeepers of hematopoiesis
CP Rodrigues, M Shvedunova, A Akhtar - Trends in Genetics, 2021 - cell.com
Hematopoiesis is the process by which both fetal and adult organisms derive the full
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …
[HTML][HTML] Multi-layered spatial transcriptomics identify secretory factors promoting human hematopoietic stem cell development
Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros
(AGM) region. Studies of model organisms defined intersecting signaling pathways that …
(AGM) region. Studies of model organisms defined intersecting signaling pathways that …
Hematopoietic stem cells and the immune system in development and aging
D Shevyrev, V Tereshchenko, TN Berezina… - International Journal of …, 2023 - mdpi.com
Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …
whole variety of cells of the immune system. Developing in the early embryo, passing …
A view of human haematopoietic development from the Petri dish
A Ditadi, CM Sturgeon, G Keller - Nature Reviews Molecular Cell …, 2017 - nature.com
Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in
vitro differentiation models that will transform our approach to the study of human …
vitro differentiation models that will transform our approach to the study of human …
Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells
via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The …
via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The …