Beyond erectile dysfunction: cGMP-specific phosphodiesterase 5 inhibitors for other clinical disorders
Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …
Polypharmacology: The science of multi-targeting molecules
Polypharmacology is a concept where a molecule can interact with two or more targets
simultaneously. It offers many advantages as compared to the conventional single-targeting …
simultaneously. It offers many advantages as compared to the conventional single-targeting …
[HTML][HTML] Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors
Abstract Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases
(PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …
(PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …
A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex
We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …
Dual-target inhibitors based on HDACs: novel antitumor agents for cancer therapy
T Liu, Y Wan, Y Xiao, C Xia, G Duan - Journal of medicinal …, 2020 - ACS Publications
Histone deacetylases (HDACs) play an important role in regulating target gene expression.
They have been highlighted as a novel category of anticancer targets, and their inhibition …
They have been highlighted as a novel category of anticancer targets, and their inhibition …
From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology
C Albertini, A Salerno… - Medicinal Research …, 2021 - Wiley Online Library
The continued drug discovery failures in complex neurodegenerative diseases, including
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
[HTML][HTML] Small molecule therapeutics for tauopathy in Alzheimer's disease: walking on the path of most resistance
Alzheimer's disease (AD) is the most common form of dementia characterized by presence
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …
Multitarget therapeutic strategies for Alzheimer's disease: Review on emerging target combinations
Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective
Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …
targets which have been studied intensively in the past few decades. Although several drugs …
The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease
S Yang, R Zhang, G Wang, Y Zhang - Translational neurodegeneration, 2017 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disease, which is associated with
learning and memory impairment in the elderly. Recent studies have found that treating AD …
learning and memory impairment in the elderly. Recent studies have found that treating AD …