Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

Necroptosis is a form of regulated cell death that critically depends on receptor-interacting
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting
protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like …

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …

Regulated necrosis, termed necroptosis, is negatively regulated by caspase-8 and is
dependent on the kinase activity of RIPK1 and RIPK3. Necroptosis leads to rapid plasma …

Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the
pathophysiologically predominant pathway that leads to regulated necrosis of parenchymal …

Intestinal immune homeostasis depends on a tightly regulated cross talk between
commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs),,,. Epithelial …

The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of
programmed necrosis/necroptosis, an inflammatory form of cell death with important …