Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

Objective: To comparatively analyze the efficacy, acceptability, and tolerability of various
augmentation agents in adult patients with treatment-resistant depression. Data Sources: An …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

A revision of the 2000 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken to …

OBJECTIVE: To summarize and discuss the conceptual and operational definitions of
treatment resistant/refractory depression (TRD) by systematically reviewing randomized …

Abstract Treatment-resistant depression (TRD) presents major challenges for both patients
and clinicians. There is no universally accepted definition of TRD, but results from the US …

Abstract The Royal Australian and New Zealand College of Psychiatrists (RANZCP) is
coordinating the development of clinical practice guidelines (CPGs) in psychiatry, funded …

Treatment resistant depression (TRD) is associated with poor outcomes, but a consensus is
lacking in the literature regarding which compound represents the best pharmacological …

Several classes of antidepressant drug exist, divided into three broad families, the
monoamine reuptake inhibitors, the monoamine oxidase inhibitors and the monoamine …

Background: Response to antidepressant drug therapy is less than optimal for a
considerable proportion of depressed patients; at present, however, few data exist to guide …