The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) remains a challenge because of
the large variability of the clinical scenario, especially in its early stages, which may mimic …

Viruses are a common cause of central nervous system (CNS) infections with many host,
agent, and environmental factors influencing the expression of viral diseases. Viruses can …

Microglia are the resident immune cells of the central nervous system contributing
substantially to health and disease. There is increasing evidence that inflammatory microglia …

Transverse myelitis is an acute inflammatory disease of the spinal cord, characterized by
rapid onset of bilateral neurological symptoms. Weakness, sensory disturbance, and …

Various neuropathologies produce hyperintense signals on T2-weighted or fluid-attenuated
inversion recovery sequences of the temporal lobes. Recognition of the distribution pattern …

Objective The number of diagnosed fatal encephalitis cases in humans caused by the
classical Borna disease virus (BoDV‐1) has been increasing, ever since it was proved that …

Viral infections of the central nervous system (CNS) range in clinical severity, with the most
severe proving fatal within a matter of days. Some of the more than 100 different viruses …

To explore the autoimmune response and outcome in the central nervous system (CNS) at
the onset of viral infection and correlation between autoantibodies and viruses. Methods A …

Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a
fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising …