Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Dynamic modulation and posttranslational modification of proteins are tightly controlled
biological processes that occur in response to physiological cues. One such dynamic …

Viral proteins are known to be methylated by host protein arginine methyltransferases
(PRMTs) necessary for the viral life cycle, but it remains unknown whether severe acute …

Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers.
Both late tumor diagnosis and tolerance to available chemical therapy increase patient …

Protein arginine methylation is a common post-translational modification involved in
numerous cellular processes including transcription, DNA repair, mRNA splicing and signal …

Mutations of the Plekhm1 gene in humans and rats cause osteopetrosis, an inherited bone
disease characterized by diminished bone resorption by osteoclasts. PLEKHM1 binds to …

Background FAM98A is a microtubule-associated protein involved in cell proliferation and
migration, and is frequently dysregulated in epithelial cancers. But its role in the …

Circular RNAs (circRNAs) as small non-coding RNAs with cell, tissue, or organ-specific
expression accomplish a broad array of functions in physiological and pathological …

Homeobox (HOX) genes are conserved transcription factors which determine the anterior-
posterior body axis patterning. HOXD8 is a member of HOX genes deregulated in several …

Characterization of protein arginine dimethylation presents significant challenges due to its
occurrence at the substoichiometric level. To enable a targeted MS/MS analysis of these …