Lactate saturation limits bicarbonate detection in hyperpolarized 13C‐pyruvate MRI of the brain
Purpose To investigate the potential effects of [1‐13C] lactate RF saturation pulses on [13C]
bicarbonate detection in hyperpolarized [1‐13C] pyruvate MRI of the brain. Methods …
bicarbonate detection in hyperpolarized [1‐13C] pyruvate MRI of the brain. Methods …
The Effect of Marginal Zn2+ Excess Released from Titanium Coating on Differentiation of Human Osteoblastic Cells
M Bartmański, Ł Pawłowski, A Knabe… - … Applied Materials & …, 2024 - ACS Publications
Composite coatings based on chitosan and zinc nanoparticles (ZnNPs) were successfully
produced on Ti13Zr13Nb substrates by cathodic electrophoretic deposition (EPD). The …
produced on Ti13Zr13Nb substrates by cathodic electrophoretic deposition (EPD). The …
Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1‐13C]pyruvate
Purpose Pyruvate, produced from either glucose, glycogen, or lactate, is the dominant
precursor of cerebral oxidative metabolism. Pyruvate dehydrogenase (PDH) flux is a direct …
precursor of cerebral oxidative metabolism. Pyruvate dehydrogenase (PDH) flux is a direct …
Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids—A New Method to Characterize the Metabolism of Brain …
Organoids are a powerful tool in the quest to understand human diseases. As the
developing brain is extremely inaccessible in mammals, cerebral organoids (COs) provide a …
developing brain is extremely inaccessible in mammals, cerebral organoids (COs) provide a …
Accumulation of 3‐aminopropylphosphonate in the ex vivo brain observed by phosphorus‐31 nuclear magnetic resonance
D Shaul, B Grieb, N Lev‐Cohain, J Sosna… - NMR in …, 2022 - Wiley Online Library
3‐aminopropylphosphonate (3‐APP) is known for its use as an exogenous indicator of
extracellular volume and pH in phosphorus‐31 nuclear magnetic resonance (31P NMR) …
extracellular volume and pH in phosphorus‐31 nuclear magnetic resonance (31P NMR) …
Real‐time influence of intracellular acidification and Na+/H+ exchanger inhibition on in‐cell pyruvate metabolism in the perfused mouse heart: A 31P‐NMR and hyperpolarized …
Disruption of acid–base balance is linked to various diseases and conditions. In the heart,
intracellular acidification is associated with heart failure, maladaptive cardiac hypertrophy …
intracellular acidification is associated with heart failure, maladaptive cardiac hypertrophy …
Lactate excitation limits bicarbonate detection in hyperpolarized pyruvate MRI of the brain
Synopsis In hyperpolarized [1-13 C] pyruvate MRI of the brain, pyruvate-to-bicarbonate
conversion, representing oxidative metabolism, is detected at low levels, despite the highly …
conversion, representing oxidative metabolism, is detected at low levels, despite the highly …