The epigenome dynamically regulates gene expression and guides cellular differentiation
throughout the lifespan of eukaryotic organisms. Recent advances in clustered regularly …

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) system has revolutionized the ability to edit the mammalian genome, providing …

Treating solid malignancies with chimeric antigen receptor (CAR) T cells typically results in
poor responses. Immunomodulatory biologics delivered systemically can augment the cells' …

There remains a critical need for the precise control of CRISPR (clustered regularly
interspaced short palindromic repeats)-based technologies. Here, we engineer a set of …

Genome editing technology has become one of the hottest research areas in recent years.
Among diverse genome editing tools, the Clustered Regularly Interspaced Short …

Prokaryotes possess an adaptive immune system using various CRISPR associated (Cas)
genes to make an archive of records from invading phages and eliminate them upon re …

The CRISPR/Cas system was first discovered as a defense mechanism in bacteria and is
now used as a tool for precise gene-editing applications. Rapidly evolving, it is increasingly …

Body temperature is maintained at around 37° C in humans, but may rise to 40° C or more
during high‐grade fever, which occurs in most adults who are seriously ill. However …

Temperature is a physical cue that is easy to apply, allowing cellular behaviors to be
controlled in a contactless and dynamic manner via heat-inducible/repressible systems …

Manipulating gene expression in the host genome with high precision is crucial for
controlling cellular function and behavior. Here, we present a precise, non-invasive, and …