Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …

The programmed removal of organelles from differentiating lens fibre cells contributes
towards lens transparency through formation of an organelle-free zone (OFZ). Disruptions in …

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic
malignancies and has a poor prognosis due to relatively unspecific early symptoms, and …

The lysosomal aspartic protease cathepsin D (cath-D) is overexpressed and hyper-secreted
by epithelial breast cancer cells. This protease is an independent marker of poor prognosis …

Physiological cell death is a key mechanism that ensures appropriate development and
maintenance of tissues and organs in multicellular organisms. Most structures in the …

Cancer remains a major and leading health problem worldwide. Lack of early diagnosis,
chemoresistance, and recurrence of cancer means vast research and development are …

The lysosomal aspartic protease Cathepsin D (CD) is ubiquitously expressed in eukaryotic
organisms. CD activity is essential to accomplish the acid-dependent extensive or partial …

Epithelial ovarian cancer (EOC) frequently metastasises to the omentum, a process that
requires pro-angiogenic activation of human omental microvascular endothelial cells …

Micromass cultures of embryonic limb skeletal progenitors replicate the tissue remodelling
processes observed during digit morphogenesis. Here, we have employed micromass …

Elimination of the interdigital web is considered to be the classical model for assessing
apoptosis. So far, most of the molecules described in the process have been connected to …