BCG immunotherapy for bladder cancer—the effects of substrain differences

C Gan, H Mostafid, MS Khan, DJM Lewis - Nature Reviews Urology, 2013 - nature.com
Genetic mutations have been progressively introduced to BCG by repeated serial passage
over many decades of its culture and global dissemination. Thus, marked differences exist in …

Applications of bacillus Calmette–Guerin and recombinant bacillus Calmette–Guerin in vaccine development and tumor immunotherapy

Y Zheng, YW Naguib, Y Dong, Y Shi… - Expert review of …, 2015 - Taylor & Francis
Bacillus Calmette–Guerin (BCG) vaccines are attenuated live strains of Mycobacterium
bovis and are among the most widely used vaccines in the world. BCG is proven to be …

Genistein induces apoptosis and autophagy in human breast MCF-7 cells by modulating the expression of proapoptotic factors and oxidative stress enzymes

RF Prietsch, LG Monte, FA Da Silva, FT Beira… - Molecular and cellular …, 2014 - Springer
Breast cancer is one of the common tumors occurring in woman and despite treatment, the
prognostic is poor. Genistein, a soy isoflavone, has been reported to have chemopreventive …

Brazilian red propolis induces apoptosis‐like cell death and decreases migration potential in bladder cancer cells

KR Begnini, PM Moura de Leon… - Evidence‐Based …, 2014 - Wiley Online Library
Natural products continue to be an invaluable resource of anticancer drug discovery in
recent years. Propolis is known for its biological activities such as antimicrobial and …

Melatonin delivery by nanocapsules during in vitro bovine oocyte maturation decreased the reactive oxygen species of oocytes and embryos

MH Remião, CG Lucas, WB Domingues, T Silveira… - Reproductive …, 2016 - Elsevier
In this work, a promising approach to increase the advantageous properties of melatonin
through its encapsulation into lipid-core nanocapsules (LNC) was examined. Oocytes were …

Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells

LG Monte, T Santi-Gadelha, LB Reis, E Braganhol… - Biotechnology …, 2014 - Springer
The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus
esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast …

Antitumor potential of 1-thiocarbamoyl-3, 5-diaryl-4, 5-dihydro-1H-pyrazoles in human bladder cancer cells

JW Tessmann, J Buss, KR Begnini, LM Berneira… - Biomedicine & …, 2017 - Elsevier
Bladder cancer is a genitourinary malignant disease common worldwide. Current
chemotherapy is often limited mainly due to toxicity and drug resistance. Thus, there is a …

Proteomic of goat milk whey and its bacteriostatic and antitumour potential

GKVV Medeiros, RCRE Queiroga, WKA Costa… - International journal of …, 2018 - Elsevier
Goat whey is normally discarded in the milk processing industry. However, several studies
have addressed its biological properties and possible use in human or animal diet. The …

Mycobacterium bovis BCG in metastatic melanoma therapy

MLR Benitez, CB Bender, TL Oliveira… - Applied microbiology …, 2019 - Springer
Melanoma is the most aggressive form of skin cancer, with a high mortality rate and with
96,480 new cases expected in 2019 in the USS. BRAF V600E, the most common driver …

The melding of drug screening platforms for melanoma

GK Couto, NV Segatto, TL Oliveira, FK Seixas… - Frontiers in …, 2019 - frontiersin.org
The global incidence of cancer is rising rapidly and continues to be one of the leading
causes of death in the world. Melanoma deserves special attention since it represents one of …