Highlights•Skeletal muscle secretes myokines that exert autocrine paracrine and endocrine
effects.•Paracrine factors modulate muscle angiogenesis, adipogenesis, and …

Skeletal muscle exhibits superb plasticity in response to changes in functional demands.
Chronic increases of skeletal muscle contractile activity, such as endurance exercise, lead to …

A decline in capillary density and blood flow with age is a major cause of mortality and
morbidity. Understanding why this occurs is key to future gains in human health. NAD …

Background We evaluated angiogenic responses in the left ventricular muscle and aerobic
capacity according to exercise type (aerobic, resistance, combined) in aged rats. Methods In …

Gut microbiota is involved in the development of several chronic diseases, including
diabetes, obesity, and cancer, through its interactions with the host organs. It has been …

The role of capillaries is to serve as the interface for delivery of oxygen and removal of
metabolites to/from tissues. During the past decade there has been a proliferation of studies …

In skeletal muscle, growth of capillaries is an important adaptation to exercise training that
secures adequate diffusion capacity for oxygen and nutrients even at high‐intensity exercise …

Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output
leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate …

The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

This chapter is devoted to the role of genetic variation and gene-exercise interactions in the
biology of adaptation to exercise. There is evidence from genetic epidemiology research that …