Experimental approaches directed at addressing these issues are limited by several
considerations. First, the close association between obesity and OSA often obscures …

Obstructive sleep apnoea (OSA) is a common disorder in which repetitive apnoeas expose
the cardiovascular system to cycles of hypoxia, exaggerated negative intrathoracic pressure …

Sleep apnea occurs in 5% to 10% of the general population, regardless of race and
ethnicity. 1 By contrast, in patients with cardiovascular diseases (CVDs), its prevalence …

Disturbances in cardiovascular neural regulation, influencing both disease course and
survival, progress as heart failure worsens. Heart failure due to left ventricular systolic …

Synchronization of molecular, metabolic, and cardiovascular circadian oscillations is
fundamental to human health. Sleep-disordered breathing, which disrupts such temporal …

The regulatory landscape for device-based heart failure (HF) therapies has seen a major
shift in the last 7 years. In 2013, the US Food and Drug Administration released guidance for …

Cardiovascular autonomic imbalance, a cardinal phenotype of human heart failure, has
adverse implications for symptoms during wakefulness and sleep; for cardiac, renal, and …

Obstructive sleep apnea (OSA) exposes the cardiovascular system to intermittent hypoxia,
oxidative stress, systemic inflammation, exaggerated negative intrathoracic pressure …

Heart failure (HF) is a syndrome characterized by upregulation of the sympathetic nervous
system and abnormal responsiveness of the parasympathetic nervous system. 1 Evidence …

Background Adverse effects of obstructive sleep apnea (OSA), including sleep deprivation,
can contribute to the progression of heart failure. The usual indication to diagnose and treat …