lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of
cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in …

Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Reactive oxygen species, particularly superoxide, promote endothelial dysfunction and
alterations in vascular structure. It is increasingly recognized that inflammatory cytokines …

Perivascular adipose tissue (PVAT), the adipose tissue that surrounds most of the
vasculature, has emerged as an active component of the blood vessel wall regulating …

The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling
that are involved in neuronal development, cellular differentiation, cell migration, cancer …

Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of
polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12 …

IL‐6 is a pleiotropic cytokine that participates in normal functions of the immune system,
haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and …

Pulmonary hypertension is defined as a group of diseases characterized by a progressive
increase in pulmonary vascular resistance (PVR), which leads to right ventricular failure and …