Phelan–McDermid syndrome (PMS) is a genetic condition caused by SHANK3
haploinsufficiency and characterized by a wide range of neurodevelopmental and systemic …

Background People with intellectual disabilities are more likely to experience sleep
problems, which can affect quality of life, physical health, mental health and well‐being …

Disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental
disorder (NDD) called SYNGAP1-related intellectual disability (SRID). Without functional …

SYNGAP1 is a Ras-GTPase-activating protein highly enriched at excitatory synapses in the
brain. De novo loss-of-function mutations in SYNGAP1 are a major cause of genetically …

Background Patients with autism spectrum disorder (ASD) experience high rates of sleep
disruption beginning early in life; however, the developmental consequences of this …

Background Sleep problems are regularly reported in people with intellectual disabilities.
Recent years have seen a substantial increase in studies comparing sleep in people with …

Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …

Background and aims SYNGAP1-related disorder (SYNGAP1-RD) is a prevalent genetic
form of Autism Spectrum Disorder and Intellectual Disability (ASD/ID) and is caused by de …

Sleep is crucial for brain development. Sleep disturbances are prevalent in children with
autism spectrum disorder (ASD). Strikingly, these sleep problems are positively correlated …

Study Objectives: Sleep disturbances are common in neurodevelopmental disorders,
affecting patients and caregivers' quality of life. SYNGAP1-associated syndrome, a rare …