The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

Women with germline BRCA1 mutations (BRCA1+/mut) have increased risk for hereditary
breast cancer. Cancer initiation in BRCA1+/mut is associated with premalignant changes in …

We report that human secretory breast carcinoma (SBC), a rare subtype of infiltrating ductal
carcinoma, expresses the ETV6-NTRK3 gene fusion previously cloned in pediatric …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

Neurotrophins have long been known to promote the survival and differentiation of
vertebrate neurons. However, these growth factors can also induce cell death through the …

Background Research has indicated that the emergence of Schwann cells around
premalignant lesions of colon cancer might be an early indicator promoting the onset of …

Alzheimer's disease (AD), characterized by progressive dementia and deterioration of
cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are …

The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine
kinases and the structurally unrelated tumor necrosis factor receptor family member …

Intracellular calcium (Ca2+) concentration ([Ca2+] i) is a key determinant of cell fate and is
implicated in carcinogenesis. Membrane ion channels are structures through which ions …