White adipocyte dysfunction and obesity-associated pathologies in humans

CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

[HTML][HTML] The role of exercise in obesity-related cancers: Current evidence and biological mechanisms

EA Larson, M Dalamaga, F Magkos - Seminars in cancer biology, 2023 - Elsevier
Cancer ranks among the five leading causes of death in almost all countries and has
important repercussions for individual and public health, the healthcare system, and society …

Association between insulin resistance and cardiovascular disease risk varies according to glucose tolerance status: a nationwide prospective cohort study

T Wang, M Li, T Zeng, R Hu, Y Xu, M Xu, Z Zhao… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE To investigate whether the association between insulin resistance and
cardiovascular disease (CVD) differs by glucose tolerance status. RESEARCH DESIGN …

[PDF][PDF] Metabolic syndrome and its association with nonalcoholic steatohepatitis

F Bril, A Sanyal, K Cusi - Clinics in Liver Disease, 2023 - Elsevier
There is substantial debate about the intrinsic relationship between insulin resistance, the
metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD). While NAFLD has …

Liver insulinization as a driver of triglyceride dysmetabolism

JR Cook, MA Hawkins, UB Pajvani - Nature Metabolism, 2023 - nature.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is an increasingly prevalent
fellow traveller with the insulin resistance that underlies type 2 diabetes mellitus. However …

Therapeutic activity of green tea epigallocatechin-3-gallate on metabolic diseases and non-alcoholic fatty liver diseases: The current updates

A James, K Wang, Y Wang - Nutrients, 2023 - mdpi.com
Green tea polyphenols have numerous functions including antioxidation and modulation of
various cellular proteins and are thus beneficial against metabolic diseases including …

Obesity–an update on the basic pathophysiology and review of recent therapeutic advances

E Gjermeni, AS Kirstein, F Kolbig, M Kirchhof… - Biomolecules, 2021 - mdpi.com
Obesity represents a major public health problem with a prevalence increasing at an
alarming rate worldwide. Continuous intensive efforts to elucidate the complex …

Obesity-induced neuronal senescence: Unraveling the pathophysiological links

P Ghosh, RA Fontanella, L Scisciola, F Taktaz… - Ageing Research …, 2024 - Elsevier
Obesity is one of the most prevalent and increasing metabolic disorders and is considered
one of the twelve risk factors for dementia. Numerous studies have demonstrated that …

[HTML][HTML] How exposure to chronic stress contributes to the development of type 2 diabetes: A complexity science approach

N Merabet, PJ Lucassen, L Crielaard, K Stronks… - Frontiers in …, 2022 - Elsevier
Chronic stress contributes to the onset of type 2 diabetes (T2D), yet the underlying
etiological mechanisms are not fully understood. Responses to stress are influenced by …

Associations of body mass index, fasting insulin, and inflammation with mortality: a prospective cohort study

N Wiebe, P Muntner, M Tonelli - International Journal of Obesity, 2022 - nature.com
Background/objectives Obesity is often considered to increase the risk for premature
mortality. Higher fasting insulin and c-reactive protein are associated with higher body mass …