Electroactive biomaterials and systems for cell fate determination and tissue regeneration: design and applications

Z Liu, X Wan, ZL Wang, L Li - Advanced Materials, 2021 - Wiley Online Library
During natural tissue regeneration, tissue microenvironment and stem cell niche including
cell–cell interaction, soluble factors, and extracellular matrix (ECM) provide a train of …

Conductive polymers: opportunities and challenges in biomedical applications

T Nezakati, A Seifalian, A Tan, AM Seifalian - Chemical reviews, 2018 - ACS Publications
Research pertaining to conductive polymers has gained significant traction in recent years,
and their applications range from optoelectronics to material science. For all intents and …

Emerging applications of nanotechnology in healthcare systems: Grand challenges and perspectives

S Anjum, S Ishaque, H Fatima, W Farooq, C Hano… - Pharmaceuticals, 2021 - mdpi.com
Healthcare, as a basic human right, has often become the focus of the development of
innovative technologies. Technological progress has significantly contributed to the …

Deep learning-based predictive identification of neural stem cell differentiation

Y Zhu, R Huang, Z Wu, S Song, L Cheng… - Nature communications, 2021 - nature.com
The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …

Intrinsic mechanisms of neuronal axon regeneration

M Mahar, V Cavalli - Nature Reviews Neuroscience, 2018 - nature.com
Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Astrocyte scar formation aids central nervous system axon regeneration

MA Anderson, JE Burda, Y Ren, Y Ao, TM O'Shea… - Nature, 2016 - nature.com
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are
widely regarded as causal in this failure. Here, using three genetically targeted loss-of …

[HTML][HTML] Epitranscriptomic m6A regulation of axon regeneration in the adult mammalian nervous system

YL Weng, X Wang, R An, J Cassin, C Vissers, Y Liu… - Neuron, 2018 - cell.com
Summary N 6-methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and
regulates developmental transitions by promoting mRNA decay. Little is known about the …

Hallmarks of peripheral nerve function in bone regeneration

R Tao, B Mi, Y Hu, S Lin, Y Xiong, X Lu, AC Panayi… - Bone research, 2023 - nature.com
Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

Reducing pericyte-derived scarring promotes recovery after spinal cord injury

DO Dias, H Kim, D Holl, BW Solnestam, J Lundeberg… - Cell, 2018 - cell.com
CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to
block axonal regeneration, resulting in permanent functional deficits. We report that …

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

K Kadoya, P Lu, K Nguyen, C Lee-Kubli… - Nature medicine, 2016 - nature.com
The corticospinal tract (CST) is the most important motor system in humans, yet robust
regeneration of this projection after spinal cord injury (SCI) has not been accomplished. In …