STIM proteins: dynamic calcium signal transducers
Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
Calcium signaling and cell proliferation
Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …
TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection
M de Marcken, K Dhaliwal, AC Danielsen… - Science …, 2019 - science.org
Human blood CD14+ monocytes are bone marrow–derived white blood cells that sense and
respond to pathogens. Although innate immune activation by RNA viruses preferentially …
respond to pathogens. Although innate immune activation by RNA viruses preferentially …
Interferons as inducers of apoptosis in malignant cells
KP Kotredes, AM Gamero - Journal of Interferon & Cytokine …, 2013 - liebertpub.com
Discovered as antiviral cytokines, interferons (IFNs) are now also recognized for their
capacity to inhibit the growth of malignant cells via activation of programmed cell death …
capacity to inhibit the growth of malignant cells via activation of programmed cell death …
[HTML][HTML] Orai1-NFAT signalling pathway triggered by T cell receptor stimulation
S Srikanth, Y Gwack - Molecules and cells, 2013 - Elsevier
T cell receptor (TCR) stimulation plays a crucial role in development, homeostasis,
proliferation, cell death, cytokine production, and differentiation of T cells. Thus, in depth …
proliferation, cell death, cytokine production, and differentiation of T cells. Thus, in depth …
Host STAT2/type I interferon axis controls tumor growth
The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well‐
documented in vitro. Yet evidence of IFN‐activated STAT2 as having tumor suppressor …
documented in vitro. Yet evidence of IFN‐activated STAT2 as having tumor suppressor …
Calcium ions aggravate Alzheimer's disease through the aberrant activation of neuronal networks, leading to synaptic and cognitive deficits
PP Guan, LL Cao, Y Yang, P Wang - Frontiers in molecular …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by the
production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading …
production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading …
[HTML][HTML] Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle
Abstract Stromal interaction molecule 1 (STIM1), the sarcoplasmic reticulum (SR)
transmembrane protein, activates store-operated Ca 2+ entry (SOCE) in skeletal muscle …
transmembrane protein, activates store-operated Ca 2+ entry (SOCE) in skeletal muscle …
Role of SOCE architects STIM and Orai proteins in Cell Death
J Tanwar, RK Motiani - Cell Calcium, 2018 - Elsevier
Abstract Calcium (Ca 2+) signaling plays a critical role in regulating plethora of cellular
functions including cell survival, proliferation and migration. The perturbations in cellular Ca …
functions including cell survival, proliferation and migration. The perturbations in cellular Ca …
ORAI1 limits SARS-CoV-2 infection by regulating tonic type I IFN signaling
ORAI1 and stromal interaction molecule 1 (STIM1) are the critical mediators of store-
operated Ca 2+ entry by acting as the pore subunit and an endoplasmic reticulum–resident …
operated Ca 2+ entry by acting as the pore subunit and an endoplasmic reticulum–resident …