Magnesium is an essential element of life, involved in the regulation of metabolism and
homeostasis of all the tissues. It also regulates immunological functions, acting on the cells …

Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension,
and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Abstract Aims Transient Receptor Potential Melastatin 7 (TRPM7) cation channel is a
chanzyme (channel+ kinase) that influences cellular Mg2+ homeostasis and vascular …

Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+,
and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active …

Hypomagnesaemia is a common feature of renal Na+ wasting disorders such as Gitelman
and EAST/SeSAME syndrome. These genetic defects specifically affect Na+ reabsorption in …

As the second most abundant intracellular divalent cation, magnesium (Mg2+) is essential
for cell functions, such as ATP production, protein/DNA synthesis, protein activity, and …

In the past decades, we have extended the view of aldosterone effects beyond epithelial
tissues. New evidence regarding the aldosterone/mineralocorticoid receptor (MR) pathway …

Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia.
Mechanisms are ill-defined but dysregulation of TRPM7, a Mg2+-permeable channel/α …

Apart from the well-documented role of the renin–angiotensin–aldosterone system (RAAS)
in regulating the blood pressure and other related parameters, its role in modulating different …