The impact of immune cells on the skeletal muscle microenvironment during cancer cachexia
Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a
common comorbidity associated with cancer that results in adverse consequences for the …
common comorbidity associated with cancer that results in adverse consequences for the …
Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
Circadian rhythms are∼ 24 h cycles evident in behaviour, physiology and metabolism. The
molecular mechanism directing circadian rhythms is the circadian clock, which is composed …
molecular mechanism directing circadian rhythms is the circadian clock, which is composed …
Overexpression of ABCB1 transporter confers resistance to mTOR inhibitor WYE-354 in cancer cells
The overexpressing ABCB1 transporter is one of the key factors leading to multidrug
resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome …
resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome …
Wheel running improves fasting‐induced AMPK signaling in skeletal muscle from tumor‐bearing mice
DK Fix, BR Counts, AJ Smuder… - Physiological …, 2021 - Wiley Online Library
Disruptions to muscle protein turnover and metabolic regulation contribute to muscle
wasting during the progression of cancer cachexia. The initiation of cachexia is also …
wasting during the progression of cancer cachexia. The initiation of cachexia is also …
Recovery from FOLFOX chemotherapy-induced systemic and skeletal muscle metabolic dysfunction in mice
FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) chemotherapy is used to treat colorectal
cancer and can acutely induce metabolic dysfunction. However, the lasting effects on …
cancer and can acutely induce metabolic dysfunction. However, the lasting effects on …
Repeated eccentric contractions positively regulate muscle oxidative metabolism and protein synthesis during cancer cachexia in mice
Cancer-induced wasting is accompanied by disruptions to muscle oxidative metabolism and
protein turnover that have been associated with systemic inflammation, whereas exercise …
protein turnover that have been associated with systemic inflammation, whereas exercise …
The role of mitochondria in mediation of skeletal muscle repair
Musculoskeletal health is directly linked to independence and longevity, but disease and
aging impairs muscle mass and health. Complete repair after a pathological or physiological …
aging impairs muscle mass and health. Complete repair after a pathological or physiological …
Muscular contraction's therapeutic potential for cancer-induced wasting
Skeletal muscle atrophy and dysfunction contribute to morbidity and mortality in patients with
cancer. Cachexia pathophysiology is highly complex, given that perturbations to the …
cancer. Cachexia pathophysiology is highly complex, given that perturbations to the …
[HTML][HTML] Transcriptomic signature of cancer cachexia by integration of machine learning, literature mining and meta-analysis
K Zhao, E Ebrahimie… - Computers in Biology …, 2024 - Elsevier
Background Cancer cachexia is a severe metabolic syndrome marked by skeletal muscle
atrophy. A successful clinical intervention for cancer cachexia is currently lacking. The study …
atrophy. A successful clinical intervention for cancer cachexia is currently lacking. The study …
[HTML][HTML] Early onset physical inactivity and metabolic dysfunction in tumor-bearing mice is associated with accelerated cachexia
Cancer-induced skeletal muscle mass loss is a critical characteristic of cachexia. While
physical inactivity and systemic metabolic dysfunction can precede cachexia development …
physical inactivity and systemic metabolic dysfunction can precede cachexia development …