Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …

Alcohol use disorder (AUD) is frequently comorbid with mood disorders, and these co-
occurring neuropsychiatric disorders contribute to the development and maintenance of …

Background Microglia, the primary immune cells of the brain, are implicated in alcohol use
disorder. However, it is not known if microglial activation contributes to the transition from …

Negative affect is a core symptom domain associated with an array of neurological and
psychiatric disorders and is only partially targeted by current therapies, highlighting the need …

Background Major depressive disorder (MDD) is a recurring affective disorder that is two
times more prevalent in females than males. Evidence supports immune system dysfunction …

The neuropeptide cocaine-and amphetamine-regulated transcript (CART) has been
implicated in alcohol consumption and reward behaviours, yet mechanisms mediating these …

Background Binge alcohol drinking is a risk factor linked to numerous disease states
including alcohol use disorder (AUD). While men binge drink more alcohol than women, this …

Binge alcohol consumption among adolescents affects the developing neural networks
underpinning reward and stress processing in the nucleus accumbens (NAc). This study …

Although alcoholism and depression are highly comorbid, treatment options that take this
into account are lacking, and mouse models of alcohol (ethanol (EtOH)) intake-induced …

Withdrawal from chronic alcohol drinking can cause depression, leading to an inability to
function in daily life and an increased risk for relapse to harmful drinking. Understanding the …