Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Autonomic dysreflexia after spinal cord injury: Systemic pathophysiology and methods of management

KC Eldahan, AG Rabchevsky - Autonomic Neuroscience, 2018 - Elsevier
Traumatic spinal cord injury (SCI) has widespread physiological effects beyond the
disruption of sensory and motor function, notably the loss of normal autonomic and …

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

KL Lankford, EJ Arroyo, K Nazimek, K Bryniarski… - PloS one, 2018 - journals.plos.org
In a previous report we showed that intravenous infusion of bone marrow-derived
mesenchymal stem cells (MSCs) improved functional recovery after contusive spinal cord …

The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury

JM Schwab, Y Zhang, MA Kopp, B Brommer… - Experimental …, 2014 - Elsevier
During the transition from acute to chronic stages of recovery after spinal cord injury (SCI),
there is an evolving state of immunologic dysfunction that exacerbates the problems …

Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex

H Prüss, A Tedeschi, A Thiriot, L Lynch… - Nature …, 2017 - nature.com
Acute spinal cord injury (SCI) causes systemic immunosuppression and life-threatening
infections, thought to result from noradrenergic overactivation and excess glucocorticoid …

Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level

B Brommer, O Engel, MA Kopp, R Watzlawick, S Müller… - Brain, 2016 - academic.oup.com
Pneumonia is the leading cause of death after acute spinal cord injury and is associated
with poor neurological outcome. In contrast to the current understanding, attributing …

Gut dysbiosis impairs recovery after spinal cord injury

KA Kigerl, JCE Hall, L Wang, X Mo, Z Yu… - Journal of Experimental …, 2016 - rupress.org
The trillions of microbes that exist in the gastrointestinal tract have emerged as pivotal
regulators of mammalian development and physiology. Disruption of this gut microbiome, a …

Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship

X Sun, ZB Jones, X Chen, L Zhou, KF So… - Journal of …, 2016 - Springer
Spinal cord injury (SCI) is a devastating event that results in significant physical disabilities
for affected individuals. Apart from local injury within the spinal cord, SCI patients develop a …

Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives

JCT Chio, KJ Xu, P Popovich, S David… - Experimental …, 2021 - Elsevier
Spinal cord injury (SCI) has a complex pathophysiology. Following the initial physical
trauma to the spinal cord, which may cause vascular disruption, hemorrhage, mechanical …

Systemic inflammation in traumatic spinal cord injury

O Bloom, PE Herman, AM Spungen - Experimental neurology, 2020 - Elsevier
There are 17,730 new cases of spinal cord injury annually in the United States and up to 2.5
million individuals estimated to be living with chronic spinal cord injury (SCI)(Herman and …